APP tg Mice
APP transgenic mice over-express human APP751SL under the control of the murine Thy-1 promoter. The animals contain the same gene construct as described in Rockenstein et al. (2001). This human APP with London (717) and Swedish (670/671) mutations is expressed in high levels, resulting in an age-dependent increase of ß-amyloid1-40 and ß-amyloid1-42, the pathologically relevant forms of amyloid protein. The mice develop plaques consisting of amyloid depositions in early age, starting at 3 – 6 months in the frontal cortex. Severity of the brain pathology correlates with increasing age and behavioral deficits.
QPS Austrias' APP tg mice are a suitable model to study the influence of drugs on amyloid production, sequestration and deposition.
As with all other in vivo models we are also ready to provide samples (brain tissue, CSF etc.) from these animals for analyses in your laboratory.
We are happy to receive your inquiry.